20th century

A group of Houston businessmen purchased the site for Bush Intercontinental Airport in 1957 to preserve it until the city of Houston could formulate a plan for a new airport as a replacement for William P. Hobby Airport (at the time known as Houston International Airport). The holding company for the land was named the Jet Era Ranch Corporation, but a typographical error transformed the words "Jet Era" into "Jetero" and the airport site subsequently became known as the Jetero airport site. Although the name Jetero was no longer used in official planning documents after 1961, the airport's eastern entrance was named Jetero Boulevard. Most of Jetero Boulevard was later renamed Will Clayton Parkway.

The City of Houston annexed the Intercontinental Airport area in 1965. This annexation, along with the 1965 annexations of the Bayport area, the Fondren Road area, and an area west of Sharpstown, resulted in a gain of 51,251 acres (20,741 ha) of land for the city.

Houston Intercontinental Airport, which was the original name for the airport, opened in June 1969. The airport's IATA code of IAH derived from the stylization of the airport's name as "Intercontinental Airport of Houston." All scheduled passenger airline service formerly operated from William P. Hobby Airport moved to Intercontinental upon the airport's completion. Hobby remained open as a general aviation airport and was once again used for scheduled passenger airline jet service two years later when Southwest Airlines initiated intrastate airline service nonstop between Hobby and Dallas Love Field in 1971.

In the late 1980s, Houston City Council considered a plan to rename the airport after Mickey Leland—an African-American U.S. Congressman who died in an aviation accident in Ethiopia. Instead of renaming the whole airport, the city named Mickey Leland International Arrivals Building, which would later become Mickey Leland Terminal D, after the congressman. In April 1997, Houston City Council unanimously voted to rename the airport George Bush Intercontinental Airport/Houston, after George H. W. Bush, the 41st president of the United States. The name change took effect on May 2, 1997.

On August 28, 1990, Continental Airlines agreed to build its maintenance center at George Bush Intercontinental Airport; Continental agreed to do so because the city of Houston agreed to provide city-owned land near the airport.

At the time of the opening of IAH in 1969, domestic scheduled passenger airline flights were being operated by American Airlines, Braniff International Airways, Continental Airlines, Delta Air Lines, Eastern Air Lines, National Airlines and Houston-based Texas International Airlines, which had formerly operated as Trans-Texas Airways. International flights at this time were being flown by Pan American World Airways with ten nonstop flights a week operated with Boeing 707 jetliners to Mexico City; KLM Royal Dutch Airlines operating Douglas DC-8 jets four days a week to Amsterdam via an intermediate stop in Montreal; Braniff International with Boeing 727 services several times a week to Panama City, Panama; and Aeronaves de Mexico (now Aeroméxico) flying Douglas DC-9 jets to Monterrey, Guadalajara, Puerto Vallarta, Acapulco and Mexico City several days a week. Texas International was also operating direct services to Mexico at this time with Douglas DC-9 jets to Monterrey and Convair 600 turboprop flights to Tampico and Veracruz.

KLM introduced Boeing 747 services in 1971 and by 1974 Air France was operating four nonstop Boeing 747 flights a week to both Paris and Mexico City. Also in 1974, Continental and National were operating McDonnell Douglas DC-10 wide body jetliners into IAH while Delta was flying Lockheed L-1011 TriStar wide body jets with both types being operated on respective domestic routes from the airport by these airlines; with National also operating Boeing 747s on a Miami–Houston–Los Angeles routing.

By the late 1970s, Cayman Airways had begun nonstop flights between Grand Cayman in the Caribbean and Intercontinental with BAC One-Eleven jets. Cayman Airways served the airport for many years, operating a variety of aircraft including Boeing 727-200, Boeing 737-200, Boeing 737-300, Boeing 737-400 and Douglas DC-8 jetliners into IAH in addition to the BAC One-Eleven. In 1977, British Caledonian, commenced nonstop flights between London's Gatwick Airport and Houston with Boeing 707 service, and later with DC-10 and Boeing 747-200 service. British Airways continued operating the route, when in December 1987, BA took over B-Cal increasing its frequency on the route to double-daily.

By July 1983, the number of domestic and international air carriers serving Intercontinental had grown substantially. American, Continental, Delta and Eastern had been joined by Piedmont Airlines, Southwest Airlines, TWA, United Airlines, USAir and Western Airlines. Western was operating daily McDonnell Douglas DC-10 wide body jet services nonstop to Salt Lake City at this time, with this flight also offering one-stop services to Anchorage, Alaska.