Wick was originally a grass airfield, used by Captain E. E. Fresson's Highland Airways Ltd. (later Scottish Airways Ltd.) from 1933 until 1939.

Requisitioned by the Air Ministry during the Second World War, the airfield was extended with hard runways, hangars, and other buildings. The airfield was administered by No. 18 Group, RAF Coastal Command and No. 13 Group, RAF Fighter Command and known as Royal Air Force Wick (RAF Wick). A satellite airfield existed at RAF Skitten.

On 21 May 1941, a photographic reconnaissance Supermarine Spitfire piloted by Flying Officer Michael F. Suckling took off from Wick, and flew to Norway, in search of the German battleship Bismarck. If Bismarck were to break out into the North Atlantic, she would present a significant risk to the ships supplying Britain. 320 miles to the east of Wick, F/O Suckling found and photographed her, hiding in Grimstadfjord. This information enabled the Royal Navy to order HMS Hood and other ships, as well as aircraft, to take positions intended to track Bismarck, and prevent her from entering the North Atlantic. In ensuing battles, Hood was sunk, and, later, Bismarck.

German battleships and battle cruisers never again entered the North Atlantic, partly because of continual reconnaissance flights by the RAF of German naval activity. Many of these flights originated at Wick. On 5 March 1942, RAF reconnaissance pilot Sandy Gunn (a native of Auchterarder, Perthshire), was shot down in his Spitfire on a flight from Wick over German naval installations in Norway. He survived and became a prisoner of war, but two years later he was executed after participating in the "Great Escape" from Stalag Luft III.

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