The airport is the main base of Iberia's regional carrier Air Nostrum. Irish low-cost airline Ryanair used the airport as a hub since 2007 but decided to close it in November 2008 following a dispute over subsidies by the airport authorities. Since then the airline has continued to operate out of Valencia and reopened base in 2011. Delta Air Lines inaugurated a route to New York City, Valencia's first transatlantic service, in June 2009. It operated the flight with a Boeing 757. The company initially planned to fly year-round to New York. A few weeks after the maiden flight, however, Delta decided to make the service seasonal due to low ticket sales. It ultimately severed the link in September 2012 because of poor demand and rising fuel costs. In June 2025, Air Transat began seasonal flights to Montreal. This route was quickly extended to a year-round service. Following the route's launch, the local government in Valencia continues efforts to establish new intercontinental connections, particularly to the United States. Hungarian low-cost airline Wizz Air announced in July 2026 that it would base two aircraft in Valencia from the 26/27 winter season. Part of the base opening are the commencement of five domestic routes, marking the entry of Wizz Air into the Spanish domestic market. Later that month, it was announced that the airport terminal and infrastructure will be upgraded as part of Aena's DORA III 2027-2031 regulatory framework. The terminal will expand from the current 66,000 square meters to 140,000 square meters.