Sheppard Air Force Base is named in honor of Senator John Morris Sheppard of Texas (1875–1941), chairman of the Senate Military Affairs Committee from 1933 until his death on 9 April 1941. Senator Sheppard helped lead the fight for military preparedness before the attack on Pearl Harbor.

The base began as Sheppard Field on 300 acres (1.2 km2) just south of Kell Field. A Texas cattleman, oilman, and philanthropist, Joseph Sterling Bridwell, sold the land to the United States Army for one dollar.

It was officially opened as a United States Army Air Corps training center on 17 October 1941, following the arrival of the first military members on 14 June. As the Army Air Corps became the Army Air Forces, facilities were completed sufficiently to allow the first class of 22 aviation mechanics to enter training that October; the class graduated 23 February 1942.

During World War II, then-Sheppard Field conducted basic training, and it also trained glider mechanics, technical and flying training instructors and B-29 Superfortress flight engineers. In addition to the basic flying training, the base also provided advanced pilot training.

Sheppard Field reached its peak strength of 46,340 people while serving as a separation center for troops being discharged following World War II from September through November 1945. Sheppard Field was deactivated 31 August 1946 and declared surplus to the War Department's needs. It was transferred to the jurisdiction of the United States Army Corps of Engineers 30 April 1947. Over the next two years the Texas National Guard used the base.

USAF Training Center

Control and accountability for Sheppard Field was transferred to the Department of the Air Force 1 August 1948 and was reactivated 15 August 1948 to supplement Lackland AFB, Texas, as a basic training center renamed as Sheppard AFB. Basic training was discontinued in June 1949, but was resumed from July 1950 to May 1952.

Over the next three decades, three training schools were stationed at the base training students in aircraft maintenance, transportation, communication, civil engineering, aircrew life support and field training.

The aircraft mechanics school was transferred to Sheppard from Keesler AFB, Mississippi in April 1949 to make room for expansion of electronic training at that base. The school was renamed the Department of Aircraft Maintenance Training within the 3750th Technical School. During the Korean War (1950–1953) several airmen from such places as Greece and Turkey were trained as mechanics.

Comptroller, transportation, and intelligence training moved to Sheppard from Lowry AFB, Colorado, in the fall of 1954. Communications, refrigeration, air conditioning, and power production operator and repairman training were transferred here from F.E. Warren AFB, Wyoming in 1959. Intelligence training returned to Lowry in February 1962. Training in certain missile systems began at Sheppard in 1957 and was conducted there through September 1985 when Titan II training operations were terminated following that weapon system's retirement.

The 3950th Technical Training Wing was designated the Sheppard Technical Training Center 1 January 1959. It has had two subsequent name changes and is now the 82d Training Wing.

Helicopter pilot training was transferred from Stead AFB, Nevada in October 1965, with H-19, H-43, Bell TH-1F, CH-3C and HH-3E helicopters used for training. Additional training in airborne firefighting was also conducted, given the role of the USAF HH-43 aircraft as a local rescue and aircraft firefighting asset at selected air force bases in the United States and at air bases overseas.

The 3630th Flying Training Wing was activated in 1965, and it assumed the helicopter training program. It began providing undergraduate pilot training in the T-37 and Northrop T-38 Talon for the then-West German Air Force in August 1966. Helicopter training was discontinued in 1971 when the U.S. Army assumed responsibility for training USAF helicopter pilots at Fort Rucker, Alabama.

The 3630th Flying Training Wing also provided undergraduate pilot training for pilots of the Republic of Vietnam Air Force from 1971 to 1975. The Wing designation was changed to the 80th Flying Training Wing on 1 January 1973.

The 80th Flying Training Wing began conducting the Euro-NATO Joint Jet Pilot Training Program in 1981. This one-of-a-kind program includes 13-NATO countries. They are: Belgium, Canada, Denmark, Germany, Greece, Italy, the Netherlands, Norway, Portugal, Spain, Turkey, the United Kingdom and the United States. Approval to conduct the program was recently extended through the year 2005.

The Air Force School of Health Care Sciences offered training in dentistry, medicine, nursing (to include flight nurse training), and health-services administration. The population of the base had declined to 3,825 in 1990.

In February 1992, restructuring and downsizing of the USAF caused a realignment and renumbering of units at Sheppard.