Early years

The first scheduled flights to Chișinău started on 24 June 1926, on the route Bucharest–Galați–Chișinău and Iași. The flights were operated by CFRNA, later LARES. A commemorative plaque, describing the first flight to Chișinău, was placed in the airport.

The main terminal was built in the 1970s, with a capacity of 1,200,000 passengers per year.

Development since the 1990s

On 31 May 1995, Chișinău Airport was awarded the status of an international airport.

A major modernization and renovation of the airport was completed in 2002 by the Turkish company Akfen Holding. An annex terminal building with an area of 4,270 m2 (46,000 sq ft) was added to the renovated old terminal building of 7,600 m2 (82,000 sq ft). The project covered the construction of 3,000 m2 (32,000 sq ft) curtain walls, 3,200 m2 (34,000 sq ft) composite panels, 12,185 m2 (131,160 sq ft) asphalt road, a treatment plant with a capacity of 3,450 m3 (122,000 cu ft) a day, complete mechanical heating, ventilation and electrical systems, along with the X-ray security, luggage handling, master clock, and flight information systems. The annual capacity of the airport increased to 5.4 million passengers.

Chișinău International Airport is a member of Airports Council International.

The airport closed temporarily on 24 February 2022, as Moldovan airspace was closed in the wake of the Russian invasion of Ukraine. On 22 March 2022, the Civil Aviation Authority of Moldova partially reopened the country's airspace, which led to the resumption of operations at the airport.

On 14 March 2023, WizzAir suspended flights to/from Moldova due to concerns over airspace safety. After this, Igor Grosu, the president of the Moldovan Parliament, met with representatives of Ryanair to convince the company to operate flights at the airport, in order to replace Wizz Air as its main low-cost airline. On 17 October 2024, WizzAir announced their return to Moldova starting from 16 December 2024.