Ciampino Airport was opened in 1916 and is one of the oldest airports still in operation.

On 15 April 1924, the airship N-1 — later renamed Norge — was torn from its moorings at Ciampino by a gust of wind. Two soldiers and a civilian mechanic who had been holding the mooring lines were carried 90 metres (300 ft) into the air and fell to their deaths.

From here, on 10 April 1926, Umberto Nobile took off on the airship Norge, the first aircraft to reach the North Pole and the first to fly across the polar ice cap from Europe to America. In October 1930, the first helicopter prototype designed by Corradino D'Ascanio was tested at Ciampino Airport, reaching a record altitude of 18 m (59 ft), flight time of 8 minutes 45 seconds and 1,078 m (3,537 ft) distance flown.

During World War II, the airport was captured by Allied forces in June 1944, and afterward became a United States Army Air Forces military airfield. Although primarily used as a transport base by C-47 Skytrain aircraft of the 64th Troop Carrier Group, the Twelfth Air Force 86th Bombardment Group flew A-36 Apache combat aircraft from the airport during the immediate period after its capture from German forces.

When the combat units moved out, Air Transport Command used the airport as a major transshipment hub for cargo, transiting aircraft and personnel for the remainder of the war.

It was Rome's main airport until 1960, with traffic amounting to over 2 million passengers per year. After the opening of Leonardo da Vinci–Fiumicino Airport, Ciampino handled almost exclusively charter and executive flights for more than three decades. However, the terminal facilities were extended at the beginning of 2007 to accommodate the growing number of low-cost carrier operations.